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Abstract #0948

Using an AC/DC Coil to Improve the Line Width and Lipid Suppression for measuring 2HG in Glioma Patients at 3T

Bernhard Strasser1, Nicolas S. Arango2, Jason P. Stockmann1,3, Borjan Gagoski4,5, Bijaya Thapa1, Xianqi Li1, Wolfgang Bogner6, Julia Small7, Daniel P. Cahill7, Tracy T. Batchelor8, Jorg Dietrich8, Lawrence L. Wald1, Jacob White2, Elfar Adalsteinsson2,9, and Ovidiu C. Andronesi1

1Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 5Department of Radiology, Harvard Medical School, Boston, MA, United States, 6Department of Radiology, Medical University of Vienna, Vienna, Austria, 7Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States, 8Department Neurology, Division of Neuro-Oncology, Massachusetts General Hospital, Boston, MA, United States, 9Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States

An AC/DC 32-channel coil, which can detect signal while simultaneously alter the B0-field, was used to improve lipid inversion and the spectral linewidth for measuring 2HG. Two patients and two volunteers were measured with a spiral-based 3D sequence once with the standard scanner shim only, and once with the additional shimming of the integrated B0/Rx coil. Data quality was strongly improved, leading to improved 2HG-detection in one patient, and a decreased variability of 2HG in tumor-void areas. This can reduce the likelihood of false-positive 2HG detection. Quantification of other metabolites was additionally improved by the AC/DC shim.

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