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Abstract #0959

White matter changes in the perforant path in patients with amyotrophic lateral sclerosis

Jeroen Mollink1,2, Marlies Hiemstra1, Istvan N Huszar2, Mark Jenkinson2, Karla L Miller2, Olaf Ansorge3, Menuka Pallebage-Gamarallage3, and Anne-Marie van Cappellen van Walsum1

1Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom, 33Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share clinical overlap in terms of cognitive decline and are both characterised by the deposition of pathological TDP-43 inclusions in the brain. Here, we hypothesize that white matter degeneration of the perforant path in the hippocampus is a key feature of ALS patients developing FTD-like symptoms. Using diffusion MRI, polarized light imaging (PLI) and immunohistochemical (IHC) analysis we analysed white matter in the perforant path. dMRI and PLI measures suggest white matter degeneration in this pathway; however, densitometric analysis of IHC did not support this interpretation.

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