Abstract #0958

The alteration of white matter tract of patients with Parkinson's disease combined with the changes in tract-connected gray matter : a longitudinal report

Shi-Ming Wang¹, Sung-han Lin¹, Chih-Chien Tsai¹, Yi-Hsin Weng², Yao-Liang Chen³, Xiang-An Zhao¹, and Jiun-Jie Wang¹

¹Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan City, Taiwan, ²Neurology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, ³Radiology, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan

Parkinson's disease (PD) is a progressive nervous system disorder as a result from the loss of cell in basal ganglia. Fixel-Based Analysis can qualify the fibre density and fibre-bundle cross-section in the nerve fibre. Further, gray matter degeneration was determined by using ROI-based Analysis to investigate Mean Diffusivity (MD) changes. Therefore, the current study proposed to investigate the structural connectivity of atrophy cortical regions in the PD patients with axonal injury over a period of 2 years.

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