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Abstract #0957

Braak model investigation in Parkinson disease using multimodal MRI biomarkers

Nadya Pyatigorskaya1,2,3,4, Lydia Yahia-cherif1,3, Romain Valabregue1, Claire Ewenczyk5, Rahul Gaurav1, Marie Mongin5, Cecile Gallea1,4, Fatma Gargouri1, Eric Bardinet1, Marie Vidailhet3,4,5, and Stephane Lehericy1,2,3,4

1CENIR, ICM, Paris, France, 2Neuroradiology, APHP, Pitie Salpêtrière, Paris, France, 3Sorbonne Universite, Univ Paris 06, UMR S 1127, CNRS UMR 7225, ICM, Paris, France, 4ICM team Movement Investigation and Therapeutics, ICM, Paris, France, 5Clinique des mouvements anormaux, Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, PARIS, France

The aim of this study was to test using multimodal MRI biomarkers if the pattern of neurodegeneration in the brain of patients with Parkinson disease (PD) fits the model of disease progression proposed by Braak and al. (2003). Partial Least Squares Path-Modeling of multi-modal imaging data was in-line with the Braak pathology model confirming the gradual lesions in PD brain. While substantia nigra damage was observed in all PD patients, Braak’s model of disease progression was better followed by PD patients with idiopathic rapid eye movement sleep behavior disorders (RBD) than without RBD as demonstrated by model goodness of fit.

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