Abstract #0957

Braak model investigation in Parkinson disease using multimodal MRI biomarkers

Nadya Pyatigorskaya^1,2,3,4, Lydia Yahia-cherif^1,3, Romain Valabregue¹, Claire Ewenczyk⁵, Rahul Gaurav¹, Marie Mongin⁵, Cecile Gallea^1,4, Fatma Gargouri¹, Eric Bardinet¹, Marie Vidailhet^3,4,5, and Stephane Lehericy^1,2,3,4

¹CENIR, ICM, Paris, France, ²Neuroradiology, APHP, Pitie Salpêtrière, Paris, France, ³Sorbonne Universite, Univ Paris 06, UMR S 1127, CNRS UMR 7225, ICM, Paris, France, ⁴ICM team Movement Investigation and Therapeutics, ICM, Paris, France, ⁵Clinique des mouvements anormaux, Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, PARIS, France

The aim of this study was to test using multimodal MRI biomarkers if the pattern of neurodegeneration in the brain of patients with Parkinson disease (PD) fits the model of disease progression proposed by Braak and al. (2003). Partial Least Squares Path-Modeling of multi-modal imaging data was in-line with the Braak pathology model confirming the gradual lesions in PD brain. While substantia nigra damage was observed in all PD patients, Braak’s model of disease progression was better followed by PD patients with idiopathic rapid eye movement sleep behavior disorders (RBD) than without RBD as demonstrated by model goodness of fit.

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