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Abstract #0956

Unique Structural Backbone Topological Organization in Early Stage Parkinson’s Disease

Virendra R Mishra1, Karthik R Sreenivasan1, Xiaowei Zhuang1, Zhengshi Yang1, Dietmar Cordes1, Zoltan R Mari2, David Eidelberg3, and Ryan R Walsh4

1Imaging Research, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 3Feinstein Institute for Medical Research, Northwell Research, Manhasset, NY, United States, 4Barrow Neurological Institute, Phoenix, AZ, United States

This study shows the presence of a distinctive anatomical backbone network in early Parkinson’s Disease (PD) involving cortical and subcortical regions that are known to be involved in various stages of PD, including early PD. Impaired network segregation and rich-club measures were further found within this backbone network in PD which were associated with disease duration. We hope that by identifying a set of core abnormalities in PD structural connectivity, this will permit improved ability to understand structural-network related disease progression and also to understand changes in these core structural connectivity measures with disease-modifying therapies as they emerge.

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