Abstract #0966

Comparing imaging changes and pain response in patients with intra- or extra-osseous bone metastases treated palliatively with magnetic resonance guided high intensity focused ultrasound (MRgHIFU)

Sharon L Giles¹, Matthew RD Brown^2,3, Ian Rivens⁴, Martin Deppe⁵, Merel Huisman⁶, Young-Sun Kim⁷, Gail R ter Haar⁴, and Nandita M deSouza¹

¹CRUK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom, ²Targeted Approaches to Cancer Pain, The Institute of Cancer Research, London, United Kingdom, ³Pain Medicine Department, Royal Marsden Hospital, London, United Kingdom, ⁴Therapeutic Ultrasound, The Institute of Cancer Research, London, United Kingdom, ⁵Philips MR Therapy, Vantaa, Finland, ⁶University Medical Center Utrecht, Utrecht, Netherlands, ⁷Samsung Medical Center, Seoul, Korea, Republic of

Imaging changes and pain relief were compared in 21 patients with intra- versus extra-osseous bone metastases treated palliatively with magnetic resonance guided high intensity focused ultrasound (MRgHIFU). Thermal dose volumes measured on proton resonance frequency shift (PRFS) thermometry were significantly larger in the extra-osseous group. Intra-osseous lesions showed focal non-enhancement by Day 30, and patients had better pain response to MRgHIFU than those with extra-osseous lesions. By Day 30, 67% (6/9) patients with intra-osseous lesions were responders, compared with 33% (4/12) of patients with extra-osseous lesions. In neither group was pain response indicated by non-enhancement on Gd-T1W imaging.

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