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Abstract #0967

Real-time in-vivo tissue temperature and displacement measurements in the brain for MR-guided HIFU treatment and comparison to in-silico focused ultrasound simulation.

Valéry Ozenne1,2,3, Charlotte Constans4, Pierre Bour1,2,3, Mathieu Santin5,6, Harry Ahnine5, Romain Valabrègue5,6, Stephane Lehéricy 5,6, Jean-François Aubry4, and Bruno Quesson1,2,3

1IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, Bordeaux, France, 2Univ. Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France, 3INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France, 4Institut Langevin Ondes et Images, ESPCI ParisTech, CNRS 7587, UMRS 979 INSERM, Paris, France, 5ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, Paris, France, 6UPMC Université Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France

MR-guided High Intensity Focus Ultrasound is an appealing technology in neurosurgery. For such application, accurate targeting and monitoring are crucial. A recent sequence allowing simultaneous measurements of temperature and displacement measurements is used to identify in real-time both the focal point by Acoustic Radiation Force Intensity (ARFI) and verify the absence of heating during ARFI sonication. The method has been evaluated in vivo in a non-human primate under anesthesia with a single-element transducer. A comparison with in-silico focused ultrasound simulation is also provided.

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