Abstract #0967

Real-time in-vivo tissue temperature and displacement measurements in the brain for MR-guided HIFU treatment and comparison to in-silico focused ultrasound simulation.

Valéry Ozenne^1,2,3, Charlotte Constans⁴, Pierre Bour^1,2,3, Mathieu Santin^5,6, Harry Ahnine⁵, Romain Valabrègue^5,6, Stephane Lehéricy ^5,6, Jean-François Aubry⁴, and Bruno Quesson^1,2,3

¹IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, Bordeaux, France, ²Univ. Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France, ³INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France, ⁴Institut Langevin Ondes et Images, ESPCI ParisTech, CNRS 7587, UMRS 979 INSERM, Paris, France, ⁵ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, Paris, France, ⁶UPMC Université Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France

MR-guided High Intensity Focus Ultrasound is an appealing technology in neurosurgery. For such application, accurate targeting and monitoring are crucial. A recent sequence allowing simultaneous measurements of temperature and displacement measurements is used to identify in real-time both the focal point by Acoustic Radiation Force Intensity (ARFI) and verify the absence of heating during ARFI sonication. The method has been evaluated in vivo in a non-human primate under anesthesia with a single-element transducer. A comparison with in-silico focused ultrasound simulation is also provided.

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