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Abstract #0979

“3D-Stars” Cine MRI for the Coronary Arteries: Feasibility of Volumetric Endothelial Function Assessment

Gabriele Bonanno1,2, Robert G Weiss1,2, Davide Piccini3,4, Jérôme Yerly4,5, Sahar Soleimanifard1,2, Li Pan6, Xiaoming Bi7, Allison G Hays1, Matthias Stuber4,5, and Michael Schär2

1Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 4Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 5Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 6Siemens Healthineers, Baltimore, MD, United States, 7Siemens Healthineers, Los Angeles, CA, United States

2D coronary cine MRI has been shown to noninvasively assess coronary endothelial dysfunction, which is an early manifestation of atherosclerosis and a predictor of future acute events. However, atherosclerosis is a diffuse process and a 2D approach can only provide local measures. Recently, we introduced “3D-Stars”, a free-breathing golden-angle 3D stack-of-stars cine sequence with isotropic spatial resolution to image the proximal and mid segments of the right coronary artery. Here, we show excellent image quality at rest and during isometric-handgrip stress acquisitions and feasibility for assessing normal coronary endothelial function along the vessel in a small cohort of healthy subjects.

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