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Abstract #0992

Utility of Quantitative Exam with MR Fingerprinting and Diffusion Mapping for Characterization of Cancer Suspicious Lesions in the Transition Zone of Prostate

Ananya Panda1, Verena Carola Obmann2, Seunghee Margevicius2, Wei-Ching Lo2, Mark Schluchter2, Gregory O'Connor2, Yun Jiang2, Gregory MacLennan3, Irina Jaegar3, Lee Ponsky3, and Vikas Gulani2,3

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Case Western Reserve University, Cleveland, OH, United States, 3University Hospitals Cleveland Medical Center, Cleveland, OH, United States

This study presents the utility and two-reader reliability of a quantitative protocol comprising of MRF-relaxometry and diffusion-based ADC mapping in differentiating transition zone (TZ) prostate cancers from non- cancers. Two-reader agreement was good to excellent for T1, T2 and ADC. T1, T2 and ADC values were significantly lower in targeted biopsy-proven cancers versus non-cancers. T1+ADC combination could differentiate all cancers from non-cancers with an AUC of 0.95. For indeterminate PIRADS category 3 TZ lesions, non-cancers had significantly higher T1 and ADC than cancers and T1 may be the best property for further characterization of indeterminate TZ lesions (AUCT: 0.87 versus AUCADC: 0.84).

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