Abstract #0992

Utility of Quantitative Exam with MR Fingerprinting and Diffusion Mapping for Characterization of Cancer Suspicious Lesions in the Transition Zone of Prostate

Ananya Panda¹, Verena Carola Obmann², Seunghee Margevicius², Wei-Ching Lo², Mark Schluchter², Gregory O'Connor², Yun Jiang², Gregory MacLennan³, Irina Jaegar³, Lee Ponsky³, and Vikas Gulani^2,3

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Case Western Reserve University, Cleveland, OH, United States, ³University Hospitals Cleveland Medical Center, Cleveland, OH, United States

This study presents the utility and two-reader reliability of a quantitative protocol comprising of MRF-relaxometry and diffusion-based ADC mapping in differentiating transition zone (TZ) prostate cancers from non- cancers. Two-reader agreement was good to excellent for T₁, T₂ and ADC. T₁, T₂ and ADC values were significantly lower in targeted biopsy-proven cancers versus non-cancers. T₁+ADC combination could differentiate all cancers from non-cancers with an AUC of 0.95. For indeterminate PIRADS category 3 TZ lesions, non-cancers had significantly higher T₁ and ADC than cancers and T₁may bethe best property for further characterization of indeterminate TZ lesions (AUC_T: 0.87 versus AUC_ADC: 0.84).

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