PI-RADS v2 can be used as a valuable scoring system in clinically significant PCa detection. MRE is expected to add a new method to routine clinical practice. In this study, we combined PI-RADS v2 and MRE at 60, 90 and 120Hz and compared the diagnostic performance for differentiating PCa from prostatitis lesions. Our results showed that the diagnostic accuracy of combined PI-RADS v2+MRE approach at 90 and 120Hz were improved compared with PI-RADS v2. In conclusion, the combined PI-RADS v2+MRE approach, especially at 90 and 120Hz, may have the potential to improve PCa diagnosis.