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Abstract #1011

Multi-diffusion time DWI to detect altered microvessel structure in a rat model of hypertension

Lauren Scott1, Ben Dickie1, Shelley Rawson2, Graham Coutts1, Tim L Burnett2, Geoff JM Parker1,3, Stuart M Allan1, and Laura Parkes1

1Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 2Henry Moseley X-ray Imaging Facility, School of Materials, University of Manchester, Manchester, United Kingdom, 3Bioxydyn Limited, Manchester, United Kingdom

The role of microvascular pathology in the development and progression of dementia is currently unclear. Non-invasive methods for imaging microvessel structure are needed to study cerebrovascular alterations in-vivo. The time for water molecules to change direction relative to the diffusion time alters the measured pseudo-diffusion coefficient of intra-voxel incoherent motion (IVIM). Using multi-diffusion time multi-b-value data and a velocity autocorrelation model, the capillary segment length (l) can estimated. In this study we validate hippocampal l against vascular corrosion casts, then apply the method to study vascular structure and function in a rat model of hypertension in comparison with age-matched controls.

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