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Abstract #1012

Revisiting double diffusion encoding MRS in the mouse brain at 11.7 T: what microstructural features is metabolite diffusion sensitive to?

Mélissa Vincent1 and Julien Valette1

1Molecular Imaging Research Center (MIRCen), Commissariat à l'Energie Atomique (CEA), Fontenay-aux-Roses, France

Double diffusion encoding MRS (DDE-MRS) was shown to be highly sensitive to cell microstructure, in particular cell fiber diameter. Here we revisit the ability of DDE-MRS to probe microstructure by quantifying DDE-MRS signal for six metabolites with high accuracy. We show that signal modulation differs for neuronal and glial metabolites, yielding larger fiber diameters for glia when using a model of isotropically oriented cylinders, as previously reported. However, fiber diameters appear overestimated. Further data acquisition and modeling suggests DDE-MRS is not only sensitive to fiber diameter but also to other microstructural features, such as cell body diameter or fiber length.

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