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Abstract #1014

Effect of cell complexity and size on diffusion MRI signal: a simulation study

Andrada Ianus1, Ross Callaghan1, Daniel C. Alexander1, Hui Zhang1, and Marco Palombo1

1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom

Mapping tissue microstructure in gray matter is becoming an important field of research in diffusion MRI. Previous studies have focused on characterizing different features separately, such as neurite density, branching order or soma size. However, the combined effect of different cell morphologies and sizes on the diffusion MRI signal has not yet been investigated. This work employs numerical simulations in more realistic cell configurations to investigate the effect of soma diameter, branch diameter and branching order, on the dMRI signal and its time dependence.

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