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Abstract #1016

High Gradient Amplitude and High Slew Rate Oscillating Gradient Diffusion-Encoding for Human Brain Imaging

Ek Tsoon Tan1, Tim Sprenger2, Eric Fiveland1, Yihe Hua1, Matt A Bernstein3, Vincent B Ho4, and Thomas KF Foo1

1GE Global Research, Niskayuna, NY, United States, 2GE Healthcare, Stockholm, Sweden, 3Department of Radiology, Mayo Clinic, Rochester, MN, United States, 4Walter Reed National Military Medical Center and Uniformed Services University of the Health Sciences, Bethesda, MD, United States

Two high amplitude and slew rate head-gradient MRI systems (C3T: 80mT/m, 700T/m/s, and MAGNUS: 200 mT/m, 500 T/m/s) with significantly better performance than clinical whole-body MRI have been developed. These allow for microstructure-sensitive, oscillating-gradient-spin-echo (OGSE) diffusion-encoding to be feasibly applied for human brain imaging. An analysis of waveforms at varying gradient performances reveals that peripheral nerve stimulation and gradient slew rates limit OGSE frequencies, while gradient strength limits b-values and echo times. In vivo human imaging was performed at 3T, demonstrating significantly increased measured diffusivity in OGSE diffusion tensor imaging (DTI) as compared to standard DTI.

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