Two high amplitude and slew rate head-gradient MRI systems (C3T: 80mT/m, 700T/m/s, and MAGNUS: 200 mT/m, 500 T/m/s) with significantly better performance than clinical whole-body MRI have been developed. These allow for microstructure-sensitive, oscillating-gradient-spin-echo (OGSE) diffusion-encoding to be feasibly applied for human brain imaging. An analysis of waveforms at varying gradient performances reveals that peripheral nerve stimulation and gradient slew rates limit OGSE frequencies, while gradient strength limits b-values and echo times. In vivo human imaging was performed at 3T, demonstrating significantly increased measured diffusivity in OGSE diffusion tensor imaging (DTI) as compared to standard DTI.
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