Measurement of hepatic arterial perfusion is important for assessment of chronic liver diseases and characterization of liver lesions. The aim of this study was to investigate the capability of a 3D-PCASL sequence for measurement of arterial, portal-venous and global perfusion of the liver under free respiration. It is demonstrated that the presented method provides high quality ASL perfusion images of the liver under free breathing conditions. Results in a patient with hepatocellular carcinoma clearly indicate high and quantitatively measurable arterial perfusion of lesions, although direct measurement of the clearly lower ASL signal of arterial perfusion in normal liver tissue is usually limited by background noise.
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