There is an increasing awareness of time-of-day (TOD) effects in MRI. The underlying causes of these fluctuations may be related to diurnal physiological variations, reflecting the processes that govern transition between sleep and wake. We probed TOD effects in a prospective manner, scanning 47 healthy individuals in the morning and the same evening using a five-shell diffusion-weighted imaging protocol at 3T, where a number of important Zeitgeber signals were rigorously controlled. We found significant changes in an number of derived DWI parameters (FA, MD, AWF, MK), and speculate that these changes are pointing towards underlying mechanisms of sleep-wake homeostasis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords