Abstract #1043

Whole Brain Mapping of Subcortical U-fibers in the Human Connectome Project Data

Jing Li^1,2, Zifei Liang², Ying-Chia Lin², Choong Heon Lee², Weihong Zhang¹, Steven Baete², Yulin Ge², and Jiangyang Zhang²

¹Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China, ²New York University School of Medicine, New York, NY, United States

Although reconstruction of subcortical U-fibers from diffusion MRI data has been demonstrated before, systematic examination of U-fibers inthe brain remain challenging. In this study, we used a detailed cortical parcellation map with 78 distinct cortical regions to map more than 200 U- fibers in 60 subjects from the Human Connectome Project dataset. The results were compared to post-mortem results and chemical tracer results in monkey brains for selected fibers. We also found moderate correlations between fiber streamline numbers and resting state connectivity. By mapping all subject data to the MNI space, maps of group average U-fiber were generated.

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