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Abstract #1049

Submillimeter whole brain diffusion MRI at 7 Tesla using simultaneous multislice imaging

Xiaoping Wu1, Eddie J. Auerbach1, and Kamil Ugurbil1

1Center for Magnetic Resonance Research, Radiology, Medical School of the University of Minnesota, Minneapolis, MN, United States

Acquisition of whole-brain diffusion MRI at submillimeter resolutions has proven to be highly beneficial for probing the brain’s structure and connectivity. Here, we investigate how simultaneous multislice (SMS) imaging, a single-shot acquisition that has great success in large-scale cohort studies such as the Human Connectome Projects (HCP), can be used to achieve submillimeter whole-brain diffusion at 7 Tesla. We acquired SMS diffusion at 0.7-mm isotropic resolution using a standard body gradient. Our results show that these submillimeter data can be used to generate a whole-brain tractogram and a connectome comparable to those of the 1.05-mm HCP-style acquisition using denoising approaches.

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