Acquisition of whole-brain diffusion MRI at submillimeter resolutions has proven to be highly beneficial for probing the brain’s structure and connectivity. Here, we investigate how simultaneous multislice (SMS) imaging, a single-shot acquisition that has great success in large-scale cohort studies such as the Human Connectome Projects (HCP), can be used to achieve submillimeter whole-brain diffusion at 7 Tesla. We acquired SMS diffusion at 0.7-mm isotropic resolution using a standard body gradient. Our results show that these submillimeter data can be used to generate a whole-brain tractogram and a connectome comparable to those of the 1.05-mm HCP-style acquisition using denoising approaches.
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