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Abstract #1050

Awake and behaving mouse fMRI in Go/No-go task.

Wenjing Chen1, Zhe Han1, Xifan Chen1, Kaiwei Zhang1, Chengyu Li1, and Zhifeng Liang1

1Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China

The current study describes a novel awake and behaving mouse fMRI paradigm, which enables the functional imaging of mice brain during an olfaction based go/no-go (GNG) task. This novel paradigm incorporates a MR compatible behavioral apparatus (olfactometer, licking detection and water delivery) and awake head fixation mechanism, all specifically designed to be used with a cryogenic coil at high field. High-resolution functional images uncovered the large-scale networks that are differentially recruited in the hit vs. correct-rejection trials, with greatly limited motion artefacts. This method paved the way for future whole-brain, systematic mapping of cognitive processes in mice.

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