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Abstract #1053

Ultrahigh spatial and temporal resolution fMRI with implanted CMOS-based planar microcoil at 14.1T

Marlon Arturo Pérez-Rodas1,2, Jonas Handwerker3,4, Michael Beyerlein5, Hellmut Merkle1, Rolf Pohmann1, Jens Anders3,4, and Klaus Scheffler1,6

1High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Graduate Training Centre of Neuroscience, IMPRS for Cognitive and Systems Neuroscience, University of Tübingen, Tübingen, Germany, 3Institute of Theory of Electrical Engineering, University of Stuttgart, Stuttgart, Germany, 4Institute of Microelectronics, University of Ulm, Ulm, Germany, 5Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 6Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany

Compared to electrophysiological or optical recording of brain activity, fMRI has a rather low spatial and temporal resolution. Here, we propose the use of implanted microcoils for studying animal brain activity in-vivo with ultra high sensitivity compared to conventional coils. A fully integrated CMOS NMR transceiver containing an on-chip-microcoil, integrated amplifiers and a demodulator is used to acquire ultra-localized signal (10nl) at ultrahigh temporal resolution (5ms) showing unprecedented high speeds and spatial resolutions of the BOLD response.

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