Abstract #1053

Ultrahigh spatial and temporal resolution fMRI with implanted CMOS-based planar microcoil at 14.1T

Marlon Arturo Pérez-Rodas^1,2, Jonas Handwerker^3,4, Michael Beyerlein⁵, Hellmut Merkle¹, Rolf Pohmann¹, Jens Anders^3,4, and Klaus Scheffler^1,6

¹High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ²Graduate Training Centre of Neuroscience, IMPRS for Cognitive and Systems Neuroscience, University of Tübingen, Tübingen, Germany, ³Institute of Theory of Electrical Engineering, University of Stuttgart, Stuttgart, Germany, ⁴Institute of Microelectronics, University of Ulm, Ulm, Germany, ⁵Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ⁶Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany

Compared to electrophysiological or optical recording of brain activity, fMRI has a rather low spatial and temporal resolution. Here, we propose the use of implanted microcoils for studying animal brain activity in-vivo with ultra high sensitivity compared to conventional coils. A fully integrated CMOS NMR transceiver containing an on-chip-microcoil, integrated amplifiers and a demodulator is used to acquire ultra-localized signal (10nl) at ultrahigh temporal resolution (5ms) showing unprecedented high speeds and spatial resolutions of the BOLD response.

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