Abstract #1054

MR-Guided Pharmacological Intervention: Creating Causal Capabilities for fMRI

Walter F Block^1,2,3, Rasmus Birn^2,4, Miles Olsen², Samuel Hurley¹, Ethan K Brodsky¹, Abigail Rajala⁵, Caitlynn Filla⁵, Alan McMillan¹, Andrew L Alexander^2,4, Rick Jenison⁵, and Luis Populin⁵

¹Radiology, University of Wisconsin - Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁴Psychiatry, University of Wisconsin - Madison, Madison, WI, United States, ⁵Neuroscience, University of Wisconsin - Madison, Madison, WI, United States

Neuroscience is in need of precise interventional tools that alter local neural dynamics while monitoring whole brain network activity. We demonstrate methods to guide catheters to deliver and monitor pharmacologic alteration of a local brain region in anaesthetized Rhesus monkeys while monitoring changes in resting state functional connectivity MRI (rs-fcMRI) throughout all brain networks. Expected and unexpected alterations in rs-fcMRI after unilateral and bilateral infusions of inhibitory agents in the limbic system are provided. The approach shows promise for using the alterations to compute effective connectivity through fMRI.

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