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Abstract #1054

MR-Guided Pharmacological Intervention: Creating Causal Capabilities for fMRI

Walter F Block1,2,3, Rasmus Birn2,4, Miles Olsen2, Samuel Hurley1, Ethan K Brodsky1, Abigail Rajala5, Caitlynn Filla5, Alan McMillan1, Andrew L Alexander2,4, Rick Jenison5, and Luis Populin5

1Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 4Psychiatry, University of Wisconsin - Madison, Madison, WI, United States, 5Neuroscience, University of Wisconsin - Madison, Madison, WI, United States

Neuroscience is in need of precise interventional tools that alter local neural dynamics while monitoring whole brain network activity. We demonstrate methods to guide catheters to deliver and monitor pharmacologic alteration of a local brain region in anaesthetized Rhesus monkeys while monitoring changes in resting state functional connectivity MRI (rs-fcMRI) throughout all brain networks. Expected and unexpected alterations in rs-fcMRI after unilateral and bilateral infusions of inhibitory agents in the limbic system are provided. The approach shows promise for using the alterations to compute effective connectivity through fMRI.

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