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Abstract #1056

Line-scanning diffusion fMRI reveals a rapid-onset (<200 ms) component

Daniel Nunes1 and Noam Shemesh1

1Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal

Diffusion fMRI (dfMRI) has been proposed as a more direct means for mapping neural activity more accurately than BOLD fMRI. However, the origin of dfMRI signals is still an ongoing debate. Here, we developed a line-scanning dfMRI technique achieving very high temporal resolution (100 ms), and measured activity in the forelimb S1 upon rat forepaw stimulation. Our results show a rapid-onset (<200ms) dfMRI component that was not found in BOLD fMRI. Upon inducing hypercapnia, the fast dfMRI component was nearly unaffected while the slower dfMRI component was substantially modulated, suggesting a potentially neural origin for the former.

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