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Abstract #1057

Using BOLD fMRI to map anesthesia-induced burst suppression in humans and non-human primates

Nikoloz Sirmpilatze1,2, Jürgen Baudewig1, Judith Mylius1, Daniel Golkowski3, Andreas Ranft3, Rüdiger Ilg3, and Susann Boretius1,2

1Functional Imaging Laboratory, German Primate Center, Göttingen, Germany, 2Georg-August University of Göttingen, Göttingen, Germany, 3Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany

Deeply anesthetized and comatose states are often accompanied by a distinctive pattern of electroencephalographic activity, called “burst suppression”. This pattern’s underlying mechanism and functional significance remain largely unknown. In this work we demonstrated that burst suppression can be detected in fMRI data, without the need for accompanying measures of neural activity. We then used this fMRI approach to perform whole-brain mapping of burst suppression in anesthetized human volunteers and non-human primates. We found that burst suppression involves the same set of brain areas across primate species, and is mostly absent in primary visual and somatosensory areas.

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