Abstract #1072

The Utility of MRI for Measuring Hematocrit in Fetal Anemia

Jiawei Xu¹, An Qi Duan², Davide Marini³, Johannes Keunen⁴, Sharon Portnoy⁵, John G Sled^5,6,7, Brian W McCrindle³, John Kingdom⁴, Christopher K Macgowan^5,7, and Mike Seed³

¹Department of Physiology, University of Toronto, Toronto, ON, Canada, ²Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ³Division of Cardiology, Hospital for Sick Children, Toronto, ON, Canada, ⁴Division of Maternal-Fetal Medicine, Mount Sinai Hospital, Toronto, ON, Canada, ⁵Division of Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, ⁶Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada, ⁷Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

To determine the accuracy of MRI for estimating hematocrit in anemic fetuses, the current study compared MRI-estimated hematocrit against the gold-standard fetal blood sampling and Doppler assessment of the middle cerebral artery for peak systolic velocity (MCA-PSV). MRI-estimated hematocrit was calculated from T1 and T2 measurements of intrahepatic umbilical vein blood. MRI results correlated well with fetal blood sampling and had a higher specificity for predicting anemia than Doppler MCA-PSV. In conclusion, MRI is feasible and accurate for the detection of fetal anemia and may be used to confirm the need for blood transfusion when MCA-PSV is suggestive of anemia.

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