Abstract #1073

Dual-Imaging Modality Approach to Evaluate Cerebral Hemodynamics in Growth-Restricted Fetuses: Oxygenation and Perfusion

Brijesh Kumar Yadav^1,2, Edgar Hernandez Andrade³, Uday Krishnamurthy^1,2, Sagar Buch⁴, Pavan Jella¹, Anabela Trifan², Lami Yeo^3,5, Sonia S Hassan^3,5, E Mark Haacke^1,2, Roberto Romero^3,5, and Jaladhar Neelavalli²

¹Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, ²Department of Radiology, Wayne State University, Detroit, MI, United States, ³Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, United States, ⁴Institute for Biomedical Research, Waterloo, ON, Canada, ⁵Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, United States

Cerebral blood perfusion has shown to be a sensitive biomarker of brain sparing at early stages of fetal growth restriction (FGR) compared to conventional Doppler estimates. Blood perfusion along with cerebral blood oxygenation may provide a holistic view of the fetal brain metabolism during FGR. Fractional moving blood volume, an ultrasound-based; and susceptibility weighted imaging, an MRI-based technique were used to estimate fetal cerebral blood perfusion and oxygenation, respectively. A significantly negative and positive correlation was found between cerebral blood perfusion and oxygenation, in normal growth and FGR fetuses, respectively. This dual modality based model will improve assessment of fetal well-being.

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