Meeting Banner
Abstract #1073

Dual-Imaging Modality Approach to Evaluate Cerebral Hemodynamics in Growth-Restricted Fetuses: Oxygenation and Perfusion

Brijesh Kumar Yadav1,2, Edgar Hernandez Andrade3, Uday Krishnamurthy1,2, Sagar Buch4, Pavan Jella1, Anabela Trifan2, Lami Yeo3,5, Sonia S Hassan3,5, E Mark Haacke1,2, Roberto Romero3,5, and Jaladhar Neelavalli2

1Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, 2Department of Radiology, Wayne State University, Detroit, MI, United States, 3Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, United States, 4Institute for Biomedical Research, Waterloo, ON, Canada, 5Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, United States

Cerebral blood perfusion has shown to be a sensitive biomarker of brain sparing at early stages of fetal growth restriction (FGR) compared to conventional Doppler estimates. Blood perfusion along with cerebral blood oxygenation may provide a holistic view of the fetal brain metabolism during FGR. Fractional moving blood volume, an ultrasound-based; and susceptibility weighted imaging, an MRI-based technique were used to estimate fetal cerebral blood perfusion and oxygenation, respectively. A significantly negative and positive correlation was found between cerebral blood perfusion and oxygenation, in normal growth and FGR fetuses, respectively. This dual modality based model will improve assessment of fetal well-being.

This abstract and the presentation materials are available to members only; a login is required.

Join Here