Abstract #1076

BOLD MR Imaging of Placenta in Congenital Heart Disease: Correlation with Maternal Risk Factors, Placental Pathology, and Maternal Serum Hormones

Alexander Maad El-Ali^1,2, William Reynolds^1,2, Vidya Rajagopalan³, Vincent Lee^1,2, Julia Wallace^1,2, Jenna Schabdach^2,4, Alexandra Zehner^1,2, Michelle Gruss², Jennifer H. Adibi⁵, Vincent Schmithorst^1,2, and Ashok Panigrahy^1,2

¹Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ²Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, ³Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, ⁴Bioinformatics, University of Pittsburgh, Pittsburgh, PA, United States, ⁵Epidemiology, University of PIttsburgh, Pittsburgh, PA, United States

Intrinsic placental BOLD (pBOLD) was analyzed in mothers of congenital heart disease patients (CHD) and controls. The relationship between pBOLD temporal variance (primary outcome measure), CHD status and resting state fetal brain BOLD (rsBOLD) was specifically examined with secondary analyses exploring the relationship between pBOLD, placental histopathology, maternal risk factors (MRFs) and serum hormones (estriol, PAPP-A, β-hCG). We found that CHD patients demonstrated increased pBOLD temporal variance vs controls (p<0.001). When including the presence of MRFs (HTN, DM2, and Drug Use) as a covariate, a positive correlation between pBOLD and rsBOLD was identified (p=0.003).

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