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Abstract #1076

BOLD MR Imaging of Placenta in Congenital Heart Disease: Correlation with Maternal Risk Factors, Placental Pathology, and Maternal Serum Hormones

Alexander Maad El-Ali1,2, William Reynolds1,2, Vidya Rajagopalan3, Vincent Lee1,2, Julia Wallace1,2, Jenna Schabdach2,4, Alexandra Zehner1,2, Michelle Gruss2, Jennifer H. Adibi5, Vincent Schmithorst1,2, and Ashok Panigrahy1,2

1Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 2Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, 3Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, 4Bioinformatics, University of Pittsburgh, Pittsburgh, PA, United States, 5Epidemiology, University of PIttsburgh, Pittsburgh, PA, United States

Intrinsic placental BOLD (pBOLD) was analyzed in mothers of congenital heart disease patients (CHD) and controls. The relationship between pBOLD temporal variance (primary outcome measure), CHD status and resting state fetal brain BOLD (rsBOLD) was specifically examined with secondary analyses exploring the relationship between pBOLD, placental histopathology, maternal risk factors (MRFs) and serum hormones (estriol, PAPP-A, β-hCG). We found that CHD patients demonstrated increased pBOLD temporal variance vs controls (p<0.001). When including the presence of MRFs (HTN, DM2, and Drug Use) as a covariate, a positive correlation between pBOLD and rsBOLD was identified (p=0.003).

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