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Abstract #1077

Studying human placental function ex-vivo using perfusion methods in MRI

Daphna Link1,2, Oren Geri1,3, Liat Ben Sira2,4, Shaul Harel2,5, Tuvia Genut1, Zoya Gordon6,7, Ariel Many2,6, and Dafna Ben Bashat1,2,3

1Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 4Pediatric Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 5Pediatric Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 6Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 7Department of Medical Engineering, Tel Aviv Academic College of Engineering, Tel Aviv, Tel Aviv, Israel

The aim of this study was to investigate the functional characteristics of the human placenta ex-vivo using a novel MR compatible perfusion system. Fifteen normal human placentas were scanned ex-vivo; bolus arrival time (BAT) and flow were extracted from TWIST data. Higher BAT and lower flow values were found in placentas with peripheral cord insertion. Significant correlations were obtained between BAT and the linear distance of the blood vessel from cord insertion location. This is the first work that studied the perfusion of human placentas with MRI and provides information regarding the relation between placental structure and function.

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