Abstract #1078

Feasibility of quantitative susceptibility mapping in the human placenta

Zungho Zun^1,2,3,4, Kushal Kapse¹, Jessica Quistorff¹, Alexis Gimovsky⁵, Homa Ahmadzia⁵, Nickie Andescavage^3,6, and Catherine Limperopoulos^1,2,3,4

¹Division of Diagnostic Imaging and Radiology, Children's National Medical Center, Washington, DC, United States, ²Division of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, United States, ³Department of Pediatrics, George Washington University, Washington, DC, United States, ⁴Department of Radiology, George Washington University, Washington, DC, United States, ⁵Department of Obstetrics and Gynecology, George Washington University, Washington, DC, United States, ⁶Division of Neonatology, Children's National Medical Center, Washington, DC, United States

Quantitative susceptibility mapping (QSM) is an emerging tool for measuring magnetic susceptibility of tissue, which is used to identify hypoxia, hemorrhage, and calcifications. In this study we demonstrated the feasibility of performing QSM in the in-vivo human placenta. The measurement differences in R2* and susceptibility between 1.5 T and 3 T were consistent with our expectations and previous studies, and susceptibility was significantly reduced in response to maternal hyperoxia due to reduced deoxyhemoglobin. These results suggest that placental QSM may have the potential to assess placental function such as oxygenation.

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