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Abstract #1103

Flow-Encoded Magnetic Resonance Fingerprinting: Simultaneous Measurement of Flow, T1, & T2 with Whole Brain Coverage

Sharon Portnoy1, Eric M. Schrauben1, Vann Chau2,3, and Christopher K. Macgowan1,4

1Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, 2Pediatrics, Hospital for Sick Children, Toronto, ON, Canada, 3Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON, Canada, 4Medical Biophysics, University of Toronto, Toronto, ON, Canada

Incorporating bipolar, flow sensitizing gradients into a magnetic resonance fingerprinting (MRF) pulse sequence permits quantification of vessel flow along with static tissue T1 and T2 relaxation times. This abstract demonstrates quantification of T1, T2 and multi-directional flow with a single, volumetric, flow-encoded MRF acquisition with whole brain coverage. Comparison of T1, T2, and flow measurements with inversion recovery, spin-echo, and phase contrast techniques revealed good agreement between flow-encoded MRF and gold-standard methods. The capacity to obtain volumetric relaxometry and flow measurements with a single acquisition can support efficient, comprehensive assessments of cerebral blood flow and tissue integrity.

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