Abstract #1103

Flow-Encoded Magnetic Resonance Fingerprinting: Simultaneous Measurement of Flow, T1, & T2 with Whole Brain Coverage

Sharon Portnoy¹, Eric M. Schrauben¹, Vann Chau^2,3, and Christopher K. Macgowan^1,4

¹Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, ²Pediatrics, Hospital for Sick Children, Toronto, ON, Canada, ³Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada

Incorporating bipolar, flow sensitizing gradients into a magnetic resonance fingerprinting (MRF) pulse sequence permits quantification of vessel flow along with static tissue T₁ and T₂ relaxation times. This abstract demonstrates quantification of T₁, T₂ and multi-directional flow with a single, volumetric, flow-encoded MRF acquisition with whole brain coverage. Comparison of T₁, T₂, and flow measurements with inversion recovery, spin-echo, and phase contrast techniques revealed good agreement between flow-encoded MRF and gold-standard methods. The capacity to obtain volumetric relaxometry and flow measurements with a single acquisition can support efficient, comprehensive assessments of cerebral blood flow and tissue integrity.

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