This work extends the hybrid-state model, recently introduced to explain and optimize the dynamics of complex non-steady-state pulse sequences such as MR Fingerprinting, to magnetization transfer. We numerically optimize a hybrid-state pulse sequence for SNR efficiency and demonstrate the potential of the extended hybrid-state framework for quantification of MT effects in vivo in the human brain. Our preliminary results show good agreement with literature and demonstrate the feasibility of quantifying the fractional semi-solid pool size, as well as T1 and T2 relaxation times of the free pool, in under 10 minutes.
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