In vivo myelin imaging in MS could provide a tracking tool for demyelination and facilitating the development of new therapeutic agents that may promote remyelination. We propose to use a recently reported MRI sequence, MEX, which measures a signal linearly dependent on the myelin protons fraction in the tissue, F. The sequence was used on cuprizone fed (n=7) and control mice (n=4). The cuprizone mice exhibit significant decrease of F by 25% in the Corpus Callosum (WM), and no change in GM. This study provides a proof of usefulness of this method, for demonstrating quantification of brain white matter demyelination.
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