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Abstract #1116

A Novel MRI technique for quantifying myelin in mice brain white matter

Ella Wilczynski1, Efrat Sasson2, Uzi Eliav2, Uri Nevo1,3, and Gil Navon2

1Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 2School of Chemistry, Tel Aviv University, Tel Aviv, Israel, 3Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

In vivo myelin imaging in MS could provide a tracking tool for demyelination and facilitating the development of new therapeutic agents that may promote remyelination. We propose to use a recently reported MRI sequence, MEX, which measures a signal linearly dependent on the myelin protons fraction in the tissue, F. The sequence was used on cuprizone fed (n=7) and control mice (n=4). The cuprizone mice exhibit significant decrease of F by 25% in the Corpus Callosum (WM), and no change in GM. This study provides a proof of usefulness of this method, for demonstrating quantification of brain white matter demyelination.

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