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Abstract #1117

Simple scheme for correcting bias in axonal water fraction due to differences in compartmental transverse relaxation times

Emilie T. McKinnon1,2,3 and Jens H. Jensen2,3

1Department of Neurology, Medical University of South Carolina, Charleston, SC, United States, 2Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States, 3Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States

Neglecting differences in compartmental transverse relaxation times when modeling diffusion MRI data may affect the accuracy of estimates for microstructural parameters. Here we propose a straightforward method for correcting the bias in the axonal water fraction (AWF), as calculated from the fiber ball white matter (FBWM) model, due to T2 differences between the intra-axonal and extra-axonal compartments. This correction scheme simply requires that one additional high b-value shell be acquired at a different echo time than for the standard dataset needed for FBWM. AWF values were found to be 16% lower, on average, after the T2 correction.

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