Direct imaging of myelin is of great interest for improved diagnosis of neurodegenerative diseases. However, MR signals from myelin exhibit ultra-short T2 values in a range of 8 μs - 1 ms with a large fraction below 100 μs. Due to restrictions in sequence timing, current short-T2 imaging approaches cannot sufficiently capture these very short signals. In the present work, advanced short-T2 methodology and hardware are employed to actually image the majority of the ultra-short-T2 components in the brain. The abilities of the approach are proven in excised brain tissue and applied in vivo.
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