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Abstract #1123

QSM and R2* measurements from cortical and subcortical regions of the human brain at 7T: a Multi-Centre Reproducibility Study

Catarina Rua1, William T Clarke2, Ian D Driver3, Olivier Mougin4, Andrew T Morgan5, Stuart Clare2, Sue Francis4, Keith Muir5, David Porter5, Richard Wise3, Adrian Carpenter1, Guy Williams1, Christopher T Rodgers1, and Richard Bowtell4

1Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, 2Welcome Centre for Integrative Neuroimaging (FMRIB), University of Oxford, Oxford, United Kingdom, 3Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, 4Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 5Imaging Centre of Excellence, University of Glasgow, Glasgow, United Kingdom

Multi-site studies allow for cost-effective research at high-field by increasing the size of the healthy and patient pool.

For T2*-weighted imaging, the variability in the scanners’ shimming conditions may contribute to inconsistent numerical results.In this study we present a multi-site, multi-vendor ‘travelling-heads’ study with harmonized protocols for QSM and R2*-mapping.

Average values across cortical and subcortical ROIs are in agreement with literature, show low variance and high correlation values when comparing measurements across different scanners. R2*-mapping is more stable than QSM due to shimming differences across scanners that affect the background field.

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