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Abstract #1125

Monitoring treatment response in a murine lymphoma with Deuterium Metabolic Imaging and Spectroscopy

Felix Kreis1, Alan Wright1, Maria Fala1, De-en Hu1, and Kevin Brindle1,2

1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

We investigated whether Deuterium Metabolic Imaging (DMI) with 2H-labeled glucose can be used to monitor treatment response in a pre-clinical murine lymphoma model (EL4). Localized 2H spectra were acquired from tumors, with a time resolution of ~1min, following a bolus injection of labeled glucose. These showed inhibition of lactate labeling following treatment of the tumors with etoposide. 2D chemical shift images (2D CSI) were acquired from the tumors, but imaging treatment response may need faster image acquisition. Studies with a respiratory chain inhibitor in vitro suggested that labeling of water in EL4 tumor cells may be due, at least in part, to TCA cycle activity.

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