Abstract #1126

Novel Fluorine-18 Labeled Fe3O4@Al(OH)3 Nanoparticles as Dual Contrast Agents for Simultaneous PET/MRI

Sarah Belderbos^1,2, Manuel Antonio González-Gómez³, Yolanda Piñeiro³, Frederik Cleeren^2,4, Jens Wouters^1,2, Bella B. Manshian^2,5, Stefaan J. Soenen^2,5, Christophe M. Deroose^2,6, Willy Gsell^1,2, Guy Bormans^2,4, Jose Rivas³, and Uwe Himmelreich^1,2

¹Biomedical MRI, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium, ²MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium, ³NANOMAG Group, Department of Applied Physics, Research Technological Institute, Universidade de Santiago de Compostela, Santiago de Compostela, Spain, ⁴Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium, ⁵Nanohealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium, ⁶Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium

The emergence of (pre)clinical PET/MRI scanners is accompanied by the development of novel contrast agents. Aluminum hydroxide magnetic nanoparticles (Fe₃O₄@Al(OH)₃ NPs) can overcome limitations of iron oxide NPs after labeling with Na¹⁸F, allowing visualization with PET (high sensitivity, low background) and MRI (high resolution, longitudinal NP follow-up). In this study, labeling of novel Fe₃O₄@Al(OH)3 nanostructures with Na¹⁸F was rapid. In vivo, radiolabeled NPs accumulated in liver of healthy mice, while cells labeled with radiolabeled NPs were also seen in lungs. Our results indicate the potential of these novel nanostructures for cell tracking with high sensitivity, specificity and resolution using PET/MRI.

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