Abstract #1132

Detection of γ-glutamyl-transferase activity up-regulation in orthotopic glioma using hyperpolarized γ-glutamyl-[1-13C]glycine

Georgios Batsios¹, Chloé Najac¹, Peng Cao¹, Pavithra Viswanath¹, Elavarasan Subramani¹, Yutaro Saito², Anne Marie Gillespie¹, Hikari Yoshihara³, Peder Larson¹, Shinsuke Sando², and Sabrina Ronen¹

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²Chemistry and Biotechnology, University of Tokyo, Tokyo, Japan, ³Laboratory of functional and metabolic imaging, EPFL, Lausanne, Switzerland

γ-glutamyl-transferase (GGT) is a key enzyme in the γ-glutamyl cycle, which regulates glutathione homeostasis. Previous studies reported that the enzyme is upregulated in many human malignancies including glioblastoma, but remains low in normal brain. Here, we demonstrate the potential of hyperpolarized γ-glutamyl-[1-¹³C]glycine as a probe for GGT activity in the brain by demonstrating that its conversion to [1-¹³C]glycine is significantly higher in animals with orthotopic glioblastoma tumors when compared to healthy animal brains.

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