Meeting Banner
Abstract #1132

Detection of γ-glutamyl-transferase activity up-regulation in orthotopic glioma using hyperpolarized γ-glutamyl-[1-13C]glycine

Georgios Batsios1, Chloé Najac1, Peng Cao1, Pavithra Viswanath1, Elavarasan Subramani1, Yutaro Saito2, Anne Marie Gillespie1, Hikari Yoshihara3, Peder Larson1, Shinsuke Sando2, and Sabrina Ronen1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Chemistry and Biotechnology, University of Tokyo, Tokyo, Japan, 3Laboratory of functional and metabolic imaging, EPFL, Lausanne, Switzerland

γ-glutamyl-transferase (GGT) is a key enzyme in the γ-glutamyl cycle, which regulates glutathione homeostasis. Previous studies reported that the enzyme is upregulated in many human malignancies including glioblastoma, but remains low in normal brain. Here, we demonstrate the potential of hyperpolarized γ-glutamyl-[1-13C]glycine as a probe for GGT activity in the brain by demonstrating that its conversion to [1-13C]glycine is significantly higher in animals with orthotopic glioblastoma tumors when compared to healthy animal brains.

This abstract and the presentation materials are available to members only; a login is required.

Join Here