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Abstract #1133

Hyperpolarized [1-13C]pyruvate spectroscopy assessment of the metabolic reserve in a porcine model of compensated cardiac overload

Nikolaj Bøgh1, Esben Søvsø Szocska Hansen2, Camilla Omann1, Jakob Lindhart2, Per Mose Nielsen2, Robert S. Stephenson3, Christoffer Laustsen2, Vibeke E. Hjortdal1, and Peter Agger3

1The Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark, 2The MR Research Center, Aarhus University, Aarhus, Denmark, 3Comparative Medicine Lab, Aarhus University, Aarhus, Denmark

Mitochondrial dysfunction is a hallmark of heart failure undetectable by current clinical techniques. We examined pigs with cardiac overload using hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy at rest and under stress. Mitochondrial function was determined in-vitro. Pyruvate oxidation rates were decreased in overloaded hearts, especially under stress. In-vitro mitochondrial respiration rates were decreased in tissue from overloaded hearts. In one group, we pharmacologically increased pyruvate oxidation, which led to decreased hypertrophy, increased contractile reserve and better mitochondrial respiration. Our work underlines the importance of metabolism in heart failure and suggests that stress hyperpolarized imaging may be a marker of mitochondrial dysfunction.

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