Meeting Banner
Abstract #1134

Imaging Post-Transplant Allogeneic Rats with Acquired Immune Tolerance Using Hyperpolarized [1-13C] Pyruvate MRI

Sarmad Siddiqui1, Federico Sertic1, Mehrdad Pourfathi1, Susan Rostami2, Yi Xin1, Ian Duncan1, Stephen Kadlecek1, Ali Naji2, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Surgery, University of Pennsylvania, Philadelphia, PA, United States

Post-transplant, lungs are clinically monitored using regular radiography and/or CT scans to detect rejection. We previously demonstrated that lactate-to-pyruvate ratio derived via hyperpolarized (HP) [1-13C]-pyruvate MRI is an earlier predictor of lung rejection than microCT in an orthotopic rat lung transplantation model. In this study, we imaged transplanted allogeneic lungs in a recipient rats with acquired immune tolerance to resolve the signal contribution of ischemia-reperfusion injury from that of tissue rejection. Transplanted rat lungs with acquired immune tolerance exhibit similar behavior to that of syngeneic lung transplants before abolishing their acquired tolerance.

This abstract and the presentation materials are available to members only; a login is required.

Join Here