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Abstract #1145

Longitudinal multimodal MRI monitoring of a combination therapy using hydrogen enriched water and minocycline in ischemic stroke

zhao jiang1, Renee Faith Cattell1, Christine Pol2, Xin Fang1, Dennis W Choi2, and Timothy Duong1

1Radiology, Stony Brook University, Stony brook, NY, United States, 2Neurology, Stony Brook University, Stony brook, NY, United States

Hydrogen or minocycline individually has been shown to be neuroprotective in experimental ischemic stroke. This study evaluated the efficacy of combined hydrogen enriched water with minocycline in an ischemic stroke rat stroke model using longitudinal MRI and behavioral tests using a double-blinded design. We found that the combination therapy reduced lesion volumes, white-matter damage, and behavioral deficits, compared to individual or vehicle treatment alone. These findings suggest that combination of hydrogen water with minocycline has positive therapeutic effects in ischemic stroke.

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