Abstract #1147

Molecular profiles underlying the fluid-solid transition of brain tissue during maturation: High-resolution multifrequency MR elastography of the mouse brain paired with proteomics mass spectrometry.

Jing Guo¹, Gergely Bertalan¹, Charlotte Klein², David Meierhofer³, Shuangqing Wang⁴, Stefanie Schreyer², Jürgen Braun⁵, Barbara Steiner², Carmen Infante-Duarte⁴, and Ingolf Sack¹

¹Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Max Planck Institute for Molecular Genetics, Berlin, Germany, ⁴Department for Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁵Department of Medical Informaticsy, Charité - Universitätsmedizin Berlin, Berlin, Germany

We have investigated the mechanical development of the mouse brain from 4 weeks to 20 weeks by multifrequency MR elastography and performed proteomics analysis with mass spectrometry. Highly resolved elastographic atlases of brain maturation were generated and regional analysis was performed to identify areas with age-dependent changes in viscoelasticity. In hippocampus, molecular signatures associated with macroscopically observed mechanical profile were identified, suggesting a transition from a soft-fluid to a more elastic-solid state during maturation. Combining MRE and proteomic analysis, we provide structural and functional information related to brain maturation from the molecular level up to whole-organ mechanical scale.

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