Abstract #1150

Triple Quantum Filtered Sodium Imaging at 21.1 T Reveals Dynamic Progression in a Preclinical Migraine Model

Nastaren Abad^1,2, Ghoncheh Amouzandeh^2,3, Jens T Rosenberg², Michael G Harrington⁴, and Samuel Colles Grant^1,2

¹Chemical and Biomedical Engineering, Florida State University, Tallahassee, FL, United States, ²National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, ³Physics, Florida State University, Tallahassee, FL, United States, ⁴Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States

The brain allocates >50% of its energy reserves to the regulation of sodium homeostasis, indicating the critical importance of sodium and its fluxes in normal brain as well as neurological disorders. With the goal of localizing specific changes within intra- vs. extracellular compartments, this study utilizes Triple Quantum (TQ) coherence to evaluate ²³Na fluxes in a preclinical rodent analogue of migraine. At a high spatial and temporal resolution, longitudinal scanning was performed at 21.1 T to quantify alterations in bulk and bound sodium during and following the onset of central sensitization.

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