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Abstract #1151

Chronic hepatic encephalopathy in early developing brain, neurometabolic changes differ depending on the age of disease onset, in vivo longitudinal 1H MRS study

Veronika Rackayova1, Olivier Braissant2, Valerie McLin3, and Cristina Cudalbu1

1CIBM, EPFL, Lausanne, Switzerland, 2Service of Biomedicine, Neurometabolic Unit, Lausanne University Hospital, Lausanne, Switzerland, 3Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland

Chronic hepatic encephalopathy (CHE) due to chronic liver disease (CLD) causes irreversible cognitive deficits in children. We aimed to study possible differences in neurometabolic changes in rat model of CLD&CHE depending on the age of the disease onset (post-natal day 15 vs 21), using in-vivo 1H-MRS. We showed differences in Gln, tCho, Lac, Asc, GSH and neurotransmitter concentrations between p15 and p21 pups during the evolution of the disease. These differences suggest that age of disease onset and its coincidence with neurodevelopmental processes play an important role and may result in different vulnerability to the disease depending on the age.

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