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Abstract #1156

Multimodal MRI Combined with Liver Volume for Quantitative Assessment of Liver Function in Patients With Cirrhosis

Chenxia Li1,2, Haitian Liu3, Xiang Li1, Rong Wang1, Jian Yang1,2, and Yuelang Zhang1

1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, 2Department of Biomedical Engineering, School of Life Science and Technology of Xi’an Jiaotong University, Xi'an, China, 3The Third Hospital of HeBei Medical University, Shi jiazhuang, China

This study aim to combine multimodal MRI with liver volume for quantitative assessment of liver function in patients with cirrhosis. Eighty-five subjects underwent GD-EOB-DTPA enhanced MR and IVIM-DWI.Through statistical analysis, RE, D* and Vliver/Vspleen from modeling group were selected as optimal indicators. Using multiple regression to establish a multi-parametric model for liver function assessing: F(x). The ROC analysis of the validation group showed that it had an AUC of 0.973 in distinguishing Child-Pugh A group and Child-Pugh B and C group. The results showed it could evaluate the overall liver function and expected to be a method for preoperative local liver function assessment.

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