Abstract #1156

Multimodal MRI Combined with Liver Volume for Quantitative Assessment of Liver Function in Patients With Cirrhosis

Chenxia Li^1,2, Haitian Liu³, Xiang Li¹, Rong Wang¹, Jian Yang^1,2, and Yuelang Zhang¹

¹Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, ²Department of Biomedical Engineering, School of Life Science and Technology of Xi’an Jiaotong University, Xi'an, China, ³The Third Hospital of HeBei Medical University, Shi jiazhuang, China

This study aim to combine multimodal MRI with liver volume for quantitative assessment of liver function in patients with cirrhosis. Eighty-five subjects underwent GD-EOB-DTPA enhanced MR and IVIM-DWI.Through statistical analysis, RE, D* and V_liver/V_spleen from modeling group were selected as optimal indicators. Using multiple regression to establish a multi-parametric model for liver function assessing: F(x). The ROC analysis of the validation group showed that it had an AUC of 0.973 in distinguishing Child-Pugh A group and Child-Pugh B and C group. The results showed it could evaluate the overall liver function and expected to be a method for preoperative local liver function assessment.

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