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Abstract #1157

Improved robustness of R2* mapping using spin-density projection for liver iron quantification at 3 Tesla

Xiaozhou Liu, MD1, Ivan Pedrosa, MD PhD1, Diego Hernando, PhD2, Scott Reeder, MD PhD2, and Takeshi Yokoo, MD PhD1

1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, University of Wisconsin at Madison, Madison, WI, United States

In patients with iron overload, liver iron concentration can be measured by R2- or R2*-MRI. While gradient-recalled-echo (GRE) based R2*-MRI holds practical advantages over spin-echo based R2-MRI, the R2* technique is more challenging in patients with severe iron overload with rapid signal decay. We introduce a technique known as spin density projection (SDP), which uses liver-to-subcutaneous fat spin density ratios as an internal reference to improve robustness of R2* fitting. We performed a computer simulation and retrospective analysis of GRE imaging data in 45 patients with suspected iron overload and compared R2* fitting without and with SPD. We found that SPD increased robustness by reducing standard deviation of R2* estimation.

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