Abstract #1158

Flow quantification in portal hypertension with 4D flow: comparison of a free breathing k-t accelerated sequence to a respiratory-navigated sequence

Octavia Bane^1,2, Daniel Stocker^1,2, Paul Kennedy^1,2, Stefanie Hectors^1,2, Scott Friedman³, Thomas Schiano³, Maria Isabel Fiel⁴, Swan Thung⁴, Emilie Bollache^5,6, Susanne Schnell⁵, Aaron Fischman⁷, Michael Markl^5,8, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Radiology, Northwestern University, Chicago, IL, United States, ⁶Laboratoire d'Imagerie Biomedicale, INSERM, Paris, France, ⁷Department of Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁸Biomedical Engineering, Northwestern University McCormick School of Engineering, Evanston, IL, United States

The purpose of our prospective study was to compare a free-breathing k-t GRAPPA accelerated 4D flow sequence with a standard navigator-gated sequence, and to correlate hemodynamic parameters to the hepatic venous pressure gradient (HVPG) in patients with chronic liver disease. The k-t accelerated sequence had significant (three-fold) reduction in acquisition time, while obtaining equivalent image quality and quantitative parameters in the large vessels as the standard sequence. However, there was systematic under-estimation of velocities in small arteries. Time-average velocity in the superior mesenteric vein measured with the k-t sequence was positively correlated with HVPG.

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