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Abstract #1159

Simultaneous Fat, T1 and Stiffness Quantification Using Multi-Echo, Variable Flip Angle, Spoiled-Gradient-Echo, Magnetic Resonance Elastography

Yuan Le1, Joshua Trzasko2, Kevin Glaser2, Yuxiang Zhou1, Joseph M Hoxworth1, Bradley D Bolster, Jr.3, Joel P Felmlee2, Richard L. Ehman2, and Jun Chen2

1Radiology, Mayo Clinic Arizona, Scottsdale, AZ, United States, 2Radiology, Mayo Clinic, Rochester, MN, United States, 3Siemens Healthcare, Salt Lake City, UT, United States

Hepatic fat fraction measurements using Dixon MRI and stiffness measurements using MRE provide important liver fat and fibrosis biomarkers for evaluating liver diseases. We have developed Dixon MR Elastography to measure fat fraction and stiffness in a single acquisition. In addition, by also using variable flip angles this new technique can simultaneously measure stiffness, T1, and fat fraction, thus providing even more clinically useful information in one scan. Promising results were obtained in a fat/water/gel phantom and six healthy volunteers.

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