Abstract #1160

Early analysis of hepatic PDFF and liver stiffness results in the Strong Heart Study, investigating possible factors affecting nonalcoholic fatty liver disease in an American Indian population

Walter C Henderson¹, Ying Zhang², Justin D Dvorak², Tim Mower³, Donovan S Beswick³, Sanjay K Narotam³, Alvin C Silva⁴, Tanya Wolfson⁵, Danielle N Batakis¹, Ashley L Louie¹, Yesenia Covarrubias¹, Cynthia L West⁶, Tauqeer Ali², Richard B Devereux⁷, Jonathan W Weinsaft⁷, Jason G Umans^6,8, Rohit Loomba⁹, Shelley A Cole¹⁰, Claude B Sirlin¹, and Michael S Middleton¹

¹Liver Imaging Group, Department of Radiology, UC San Diego, La Jolla, CA, United States, ²Department of Biostatistics & Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States, ³Norman Regional Health System, Norman Regional Moore, Moore, OK, United States, ⁴Department of Radiology, Mayo Clinic, Scottsdale, AZ, United States, ⁵Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, UC San Diego, La Jolla, CA, United States, ⁶Medstar Health Research Institute, Hyattsville, MD, United States, ⁷Department of Medicine (Cardiology), Weill Cornell Medicine, New York, NY, United States, ⁸Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, United States, ⁹NAFLD Research Center, Division of Gastroenterology, Department of Medicine, UC San Diego, La Jolla, CA, United States, ¹⁰Texas Biomedical Research Institute, San Antonio, TX, United States

In this analysis of early data from the Strong Heart Study, we show that advanced MRI estimates of proton-density fat fraction (PDFF) and liver stiffness can be acquired successfully in a population of American Indians. Diagnosis of diabetes, and whether participants self-report binge-drinking are collected. Too few cases have been enrolled to permit significance testing, but PDFF values are higher for diagnosed diabetes, and stiffness values are higher for self-reported binge drinking. This study offers a unique opportunity to study the possible roles of diabetes and binge drinking in nonalcoholic fatty liver disease for an at-risk population of American Indians.

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