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Abstract #1160

Early analysis of hepatic PDFF and liver stiffness results in the Strong Heart Study, investigating possible factors affecting nonalcoholic fatty liver disease in an American Indian population

Walter C Henderson1, Ying Zhang2, Justin D Dvorak2, Tim Mower3, Donovan S Beswick3, Sanjay K Narotam3, Alvin C Silva4, Tanya Wolfson5, Danielle N Batakis1, Ashley L Louie1, Yesenia Covarrubias1, Cynthia L West6, Tauqeer Ali2, Richard B Devereux7, Jonathan W Weinsaft7, Jason G Umans6,8, Rohit Loomba9, Shelley A Cole10, Claude B Sirlin1, and Michael S Middleton1

1Liver Imaging Group, Department of Radiology, UC San Diego, La Jolla, CA, United States, 2Department of Biostatistics & Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States, 3Norman Regional Health System, Norman Regional Moore, Moore, OK, United States, 4Department of Radiology, Mayo Clinic, Scottsdale, AZ, United States, 5Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, UC San Diego, La Jolla, CA, United States, 6Medstar Health Research Institute, Hyattsville, MD, United States, 7Department of Medicine (Cardiology), Weill Cornell Medicine, New York, NY, United States, 8Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, United States, 9NAFLD Research Center, Division of Gastroenterology, Department of Medicine, UC San Diego, La Jolla, CA, United States, 10Texas Biomedical Research Institute, San Antonio, TX, United States

In this analysis of early data from the Strong Heart Study, we show that advanced MRI estimates of proton-density fat fraction (PDFF) and liver stiffness can be acquired successfully in a population of American Indians. Diagnosis of diabetes, and whether participants self-report binge-drinking are collected. Too few cases have been enrolled to permit significance testing, but PDFF values are higher for diagnosed diabetes, and stiffness values are higher for self-reported binge drinking. This study offers a unique opportunity to study the possible roles of diabetes and binge drinking in nonalcoholic fatty liver disease for an at-risk population of American Indians.

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