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Abstract #1166

Novel alpha-180 SE based LINE-scanning method (SELINE) for laminar-specific fMRI

Sangcheon Choi1,2, Hang Zeng1,2, Rolf Pohmann1, Klaus Scheffler1,3, and Xin Yu1,4

1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, Tuebingen, Germany, 3Department of Biomedical Magnetic Resonance, University of Tuebingen, Tuebingen, Germany, 4MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States

Laminar-specific functional magnetic resonance imaging (fMRI) opens new possibility for studying the neuronal circuitry and functional connectivity of cortex. FLASH based line-scanning method was proposed with high temporal and spatial resolution to better characterize the fMRI onset time across the cortical layers by combining 2 saturation RF pulses. However, the imperfect RF saturation performance led to poor boundary definition of the ROI from the cortex. In this work, we propose an α-180˚ SE based line-scanning (SELINE) method, solving this problem. We will improve this method to better understand the distinct laminar-specific neuronal circuitry and functional connectivity.

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