Abstract #1171

Task-based High Angular Resolution Functional Imaging (tHARFI) shows directional contrast of BOLD signal

Kurt G Schilling¹, Katherine S Aboud², Hakmook Kang³, Zhaohua Ding^1,4, Adam W Anderson^1,5, Laurie Cutting^2,6, John C Gore^1,2,5, and Bennett A Landman^1,7,8

¹Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ²Vanderbilt Brain Institute, Nashville, TN, United States, ³Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ⁵Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁶Peabody College of Education and Human Development, Nashville, TN, United States, ⁷BIomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁸Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States

We present a method to detect and quantify correlated BOLD signals in brain white matter using task-based high angular resolution functional imaging (tHARFI). This technique measures the anisotropic component of these signals, highlighting directional differences between two different task states. The ability to quantify these correlated functional signals in white matter may improve our ability to delineate functional circuits in the brain, and complement other modalities to better understand structural and functional relationships in the brain.

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